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For instance, Atorvastatin, a Ras/MAPK inhibitor, showed encouraging results when evaluated in combination with radiotherapy and TMZ in patients with GBMs (Phase II NCT02029573) (50)

Lithocholic acid (LCA) derivatives, including 3-oxoLCA ( in vitro inhibitory effects on Th17 cells, independent of RORt modulation ( Microbiota-modulating interventions reinforce this connection

Feijtel, I

KRAS signalling has been linked to enhanced mitochondrial metabolism by various mechanisms in colorectal, lung and pancreatic cancers 8,18 , as has APC and p53 (refs