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Therefore, our study was intended to find the half maximal cytotoxic concentrations (IC 50 ) of GT, FUM and GT + FUM instead of solely relying on particular concentrations at in vivo conditions (Table 1)

Lithospermic acid improves liver fibrosis through Piezo1-mediated oxidative stress and inflammation

Recently, it has been reported that oral administration of 1 g/day of vitamin C for a period of 16 weeks resulted in the reduction of serum levels of malondialdehyde and elevation of glutathione peroxidase levels among the patients on maintenance hemodialysis (34)

Furthermore, inhibition of Rac1 activity by Rhein not only reduces oxidative stress but also affects downstream signaling pathways involved in EMT and renal fibrosis, such as the -catenin pathway (Xiong et al., 2023)