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PMID: 2032896

Its deficiency decreases -KG, impairing JMJD3/UTX demethylase activity, increasing H3K27me3, and promoting the expression of apoptosis inhibitors such as XIAP and survivin [104]

In mice in which the Flk1 (also known as Vegfr2 ) gene was targeted for disruption, the absence of both endothelial and hematopoietic development was detected, and the mice died in utero on E8.0-E9.0, indicating that Flk1 was required in the earliest stages of hematovascular development [39]