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1 Introduction Cardiometabolic syndrome (CMS) is defined by the clustering of central obesity, insulin resistance, atherogenic dyslipidemia, hypertension, and chronic low-grade inflammation, a constellation that markedly increases the risk of type 2 diabetes, cardiovascular disease, and premature mortality (1)

Some notable FDA-approved peptide drugs include: Semaglutide (Ozempic, Rybelsus) for type 2 diabetes and weight loss

Vitamin C, for instance, is most stable and bioavailable at a pH below 3.5

The analysis of the subphenotype revealed that the treatment decreased the number of M2 macrophages that were identified as the profibrotic phenotype (Fig