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Studies have shown that it can reduce the expression of pro-inflammatory cytokines such as Tumour Necrosis Factor-alpha (TNF-) and Interleukin-6 (IL-6)

The methylation cycle stalls, and folate becomes trapped in an unusable statea phenomenon clinically referred to as the "folate trap." Because the body can no longer produce adequate amounts of SAMe, the synthesis of crucial neurotransmitters drops dramatically

C., Salvi, R