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Studies utilizing genetic knockdowns or pharmacological inhibitors have shown that disruption of one antioxidant system often leads to compensatory upregulation and increased reliance on the other, underscoring their functional interdependence [45]

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Mg 2+ supports this adaptability by regulating the activity of cytoskeletal proteins, helping to preserve structural integrity and functional plasticity under hypoxic stress (Vakhrusheva et al., 2022)