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For example, Adrian Bird defined epigenetics as "the structural adaptation of chromosomal regions so as to register, signal or perpetuate altered activity states." [6] This definition would be inclusive of transient modifications associated with DNA repair or cell-cycle phases as well as stable changes maintained across multiple cell generations, but exclude others such as templating of membrane architecture and prions unless they impinge on chromosome function

Unlike enclosed shopping malls or gated spaces, passages such as BB introduce a form of stumbling-a momentary rupture in the expected flow of urban movement

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The particular importance of mutp53 is in promoting proliferation, invasion and metastatic potential through its effect on the endosomal pathway, leading to recycling of receptors and integrins