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Grinspoon S, et al

As well as feeling tired faster, we may also see a decline in the speed the body repairs itself

In practice, the combination is typically administered as a single subcutaneous injection at bedtime, 30 to 60 minutes before sleep, to align with and augment the natural nocturnal GH peak

Patients with this condition can be treated with diuretics such as amiloride or hydrochlorothiazide, which produce a volume contracted state that promotes the absorption of water in the proximal tubule, and thereby decreases the delivery of water to the collecting duct - the location of the ADH resistance (Vaidya & Kaiser, 2012)