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Adenine overload induces ferroptosis in human primary proximal tubular epithelial cells

Antioxidants 12(4):965

In summary, although current studies suggest that ferroptosis plays a central regulatory role in the pathological sequence of PVLlinking hypoxiaischemia, inflammatory infiltration, and white-matter necrosisand provides a new mechanistic basis for understanding the pathway from periventricular iron accumulation to oligodendrocyte loss and motor developmental impairment, several essential gaps remain

Metabolic modulators such as antioxidants, metformin, and melatonin also show potential by modulating mitochondrial and immune pathways