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Metformin It is a well-known antidiabetic drug that belongs to the biguanide family [89]

3.2.1 TGVS theory According to the TGVS theory, which combines blood vessels, nerves, and neurotransmitters, the trigeminal nerve and peri-vascular nerve fibers both inside and outside the skull serve as the main pathways for transmitting pain in migraines

Inhibition of Gln metabolism reduces the frequency of CSCs population in vivo and the rate of tumor growth in mouse models

As the global population continues to grow older, this disease continues to be a major public health burden, and further research on this disease is needed (325)