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Description

While safety monitoring was comprehensive, the trials were not specifically designed to detect rare adverse effects that might occur at rates lower than 1-2%, which would require much larger participant numbers

It first gained significant attention for its potential cytoprotective and organo-protective effects, particularly within the gastrointestinal tract

Flower L et al

Both univariate and multivariate Cox proportional hazards regression analyses were performed to assess the prognostic value of the drug-related signature (DRS) scores, adjusting for potential confounders