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Therapeutic approaches included pigment fragmentation (PICO, Nd:YAG, IPL, PDL), thermal loosening of the scaffoldtissue complex (radiofrequency, high-intensity focused ultrasound, warm application), mechanical dispersion (microcurrent stimulation, ultrasound, normal saline washout, gentle massage), and enzymatic degradation (hyaluronidase, lipase)

A major advance came in 1913, when Santiago Ramn y Cajal, using the gold-sublimate method, described two key astrocyte subtypes: Protoplasmic astrocytes, found in grey matter and marked by fine, elaborate processes, and fibrous astrocytes, present in white matter and distinguished by longer, fiber-like extensions

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