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A., Lan, T

It has been pointed out that one of the major challenges for islet encapsulation is the biocompatibility issue, which could generate a severe inflammatory response

53,54,55 These niche changes include increased expression of inflammatory cytokines such as CXCL14 and cell cycle inhibitors such as CDKN1C and CDKN2A, coupled with downregulation of ECM and adhesion genes, including CAV1 , SPRY1 , FN1 , and ITGB1

Pancreatitis Warn patients and guardians that abdominal pain, nausea, vomiting, and/or anorexia can be symptoms of pancreatitis and, therefore, require further medical evaluation promptly [seeWarnings and Precautions (5.5)]