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In general, high-fat diets initiate gut microbiome dysbiosis, leading to increased intestinal and bloodbrain barrier permeability, systemic immune activation, and neuroinflammation, ultimately accelerating Alzheimers pathology

Since BP@CeO x nanozymes had an effective potential ROS-resistant performance, we further detected the H 2 O 2 remaining concentration after co-incubation with different samples for 1, 4, 7, 14 and 28 days in the above-mentioned mimic physiological and pathological environments, respectively

Sodium butyrate, as discussed, has shown neuroprotective effects in multiple mouse models (AD, PD, MS) [76]

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