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While DNA methylation may be age, gender, and cell-type specific, MTHFR polymorphism might not be always associated with hypomethylation of DNA

Treatment with exogenous H2O2 (1 M) result in protein phosphorylation in U937-neo cells (28) and oxidative stress induced by 5 M H2O2 in PC12 cells significantly up-regulates neutral sphingomyelinase activity (29)