Asked recently whether the molecule is even what the original team believed it was, one of Sikirics collaborators told Undark, As long as it works and has no side effects, who cares? If you read my work, you know Im not big for pathophysiology

1 Introduction 1.1 Immune-metabolic dysregulation in metabolic diseases: an unmet therapeutic need Immune dysregulation underlies a broad range of human diseases, including metabolic disorders such as type 2 diabetes mellitus (T2DM), obesity, and metabolic dysfunction-associated steatohepatitis (MASH) ( + T cell exhaustion ( Reactive sulfur species (RSS), emerging as a distinct redox system beyond reactive oxygen species (ROS) and reactive nitrogen species (RNS), exhibit unique immunomodulatory properties ( The RSS family, comprising hydrogen sulfide (H 2 S), persulfides, polysulfides, and related sulfur-based modifications, exerts immunoregulatory functions primarily through protein persulfidation (S-Sulfhydration), a post-translational modification that alters protein conformation, activity, and interactions ( 2 S generation and downregulated expression of RSS-producing enzymes (cystathionine -synthase, CBS

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Additionally, it contributes to the formation of important molecules like glutathione, which serves a key function in protecting plants from oxidative stress by scavenging reactive oxygen species (ROS) 5,6