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IGFs Treatments in AD Animal Models Various direct and indirect interventions aimed at correcting aberrant IGF signaling in AD have been tested in several animal models, resulting in improvements in AD-like pathology and cognitive decline (refer to Tables 2 and 3)

efficacy preserved in ghrelin knockout mice

Science 273:974977

Therefore, additional research on the effects of antifibrotics on renal function in IPF patients is needed before recommending the use of antifibrotics in IPF patients with CKD