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Fu BC et al (2020) Associations of plasma trimethylamine N-oxide, choline, carnitine, and betaine with inflammatory and cardiometabolic risk biomarkers and the fecal microbiome in the Multiethnic Cohort Adiposity Phenotype Study

They had no access to behavioural interventions

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It wasnt until the 1890s that a Dutch physician working with chickens discovered the difference between a chicken (or soldier) developing the neurological disease known as beriberi was whether they were fed brown or white rice