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doi: 10.1016/j.jfca.2022.105071 278 ZhangY.TangJ.WangS.ZhouX.PengC.ZhouH.et al

Such non-specific interactions reduce the concentration of free drug, diminish effective accumulation in target tissues, and can accelerate metabolic clearance [65, 72,73,74]

10.1016/0006-8993(91)90730-j 97 KimJ

Moreover, the therapy-induced immune response may limit the efficacy by neutralizing antibodies with drugs or restrict the security through inducing inflammatory responses (215)