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Biopharmaceutical benchmarks 2018

Rishniw and Brown warn that such breeds as the CKCS "likely require breed-specific reference intervals for LVIDDN to correctly identify left ventricular enlargement." They also point out: "For example, if a dog has a LVIDDN that consistently oscillates around 1.3 (within 0.1 units), an increase to 1.6 could indicate left ventricular enlargement for that dog, despite being within the population-based reference interval." Well, in the EPIC Study, due to the lack of any inclusion criteria relevant to heart enlargement, the peers have every reason to justifiably doubt its results

Brain Res 872(12):258261