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According to the A-tau interaction hypothesis, A and tau pathology, which results in synaptic dysfunction, neuronal death, and cognitive impairment (96), is determined by the intrinsic interaction with A and tau (A42 enhances tau phosphorylation, truncation, and aggregation, while tau can increase A synthesis)

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However, most candidates may need maintenance treatments every 6 12 months to continue to have clearer and more even-toned skin for a long lasting time

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