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Enzymatic degradation of the glycocalyx is mediated by catabolic enzymes, catabolites, metalloproteinases, matrix metalloproteinases (MMPs), disintegrin and metalloproteinase domain-containing proteins (ADAMs), heparanase-1, hyaluronidase, and GPI-specific PLC AMs (6163)

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Therefore, this study aimed to compare two intranasal vitamin B12 dosage regimens (with and without loading dose) in elderly patients deficient in vitamin B12, focusing on vitamin B12 levels and three biomarkers indicative of deficiency: holotranscobalamin, methylmalonic acid, and total homocysteine