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Nonmotor symptoms varied by dystonia subtype, with generalized dystonia showing more cognitive issues, anxiety, depression, pain, and fatigue, while focal dystonia showed higher levels of pain and fatigue

doi: 10.1074/jbc.R117.803239 67 GannonMChePChenYJiaoKRobersonEDWangQ

Synthesis of the literature was thus done in a narrative manner with special focus on differentiating the known clinical evidence on antiparasitism from exploratory mechanistic or preclinical evidence

Inhibiting glycolysis through GLUT1/3, HK2, and HIF-1 blockade, modulating lipid metabolism via FASN and SREBP-1 inhibitors, and disrupting amino acid metabolism via glutaminase (GLS) and SLC7A11 inhibitors have shown promise in limiting tumor growth