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10.1038/s41598-018-20422-0 303 PuF.ChenF.ZhangZ.ShiD.ZhongB.LvX.et al (2022)

We see a functional iron deficiency when there is reduced heme synthesis or inhibition of heme synthesis either because hemoglobin production is being inhibited or is defective or iron is not being released in sufficient amounts to support hemoglobin production