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Yakuchinone A attenuated the mRNA expression of IL-6, IL-8, and TNF- in the presence of TNF- on human epidermal keratinocytes (HaCaT cells)

in a study conducted in women with and without rUTI, found that women with a history of rUTI had significantly decreased microbial richness and depleted butyrate-producing bacteria compared to controls (22)

Upon binding to androgen, AR which is otherwise sequestered in the cytoplasm translocates to nucleus and acts as sequence-specific dimerized transcription factors ( The unique metabolic processes in the prostate are well adapted to fulfill the major function as a secretory tissue to generate prostatic fluid comprised of high concentration of citrate along with zinc, lipids, and kallikrein enzymes including prostate-specific antigen (PSA) ( Figure 1 )