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High-dose effects: Water retention or joint stiffness with prolonged highdose use (300 mcg/day)

It is possible to clone and express the sequences of effective monoclonal antibodies in proper expression systems, such as mammals, yeasts or plants, and then recombinant monoclonal antibodies could be tested [74]

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Moreover, the degree of autophagy and the expression of autophagy-related genes can be used to judge drug resistance and select the treatment method, which may be helpful for the treatment of ER-positive breast cancer patients in the future