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Five PK studies all reported that children under 12 years of age metabolise paracetamol predominately by sulphation compared with adults ( n = 114 children in total) and that the adult pattern of metabolism is present beyond the age of 12 [44,45,46,47,48]

Table 1 Results of a three-way analysis of variance examining the effects of Epichlo endophyte (E), selenium concentration (Se), and treatment duration (T) on glutathione reductase activity, reduced glutathione, and oxidized glutathione in F

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doi: 10.3389/fphar.2025.1585697 Received 01 March 2025 Accepted 01 May 2025 Published 16 May 2025 Volume 16 - 2025 Edited by Irina Ielciu, University of Medicine and Pharmacy Iuliu Hatieganu, Romania Reviewed by Marco Aurelio M Freire, Federal University of Sergipe, Brazil Kulbhushan Thakur, University of Delhi, India Abu Md Ashif Ikbal, Assam University, India Alaadin E