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Response: There are a number of factors pertinent to the OPPS that may cause geometric mean costs to change from one year to the next

Expanding distributed renewable energy will require planning, market enablement, grid operations, and advanced network automation Our DSIP plan recognizes that customers want more control over their own energy usage, bills, new services, and greater reliability Plan assumes an increasing renewable energy future and our self-assessments and plans developed with this key assumption in mind DSIP Plan Approach Identified specific required DSP operational capabilities for each core DSP function Developed roadmap to address each capability Identified foundational technologies required to enable capabilities and form DSP technical platform Energy Smart Community will be used as pilot to assess feasibility of investments, leverage previously approved funding, and mitigate risk The Energy Smart Community is a demonstration project filed and approved under NYS REV Designed to pilot REV concepts in a small footprint that reduces cost and risk Intended as the first phase of a full rollout of Platform and AMI technology (not a throwaway project) Energy Smart Community will be leveraged to prove technology and market solutions and then bring them to scale Valuable learning experience that will allow us to learn and implement new technologies and processes Many platform technology elements in DSIP will be tried out first in ESC ESC is part of an approach to start a small deployment and manage risk Grid operations require ability to distribute power effectively in real time Integrated system planning seeks to provide beneficial locations to market participants Market enablement requires provision of data to customers and market participants Energy Smart Community key aspect of Avangrids DSIP Energy Smart Community will be a concentrated test of our ability to be smart integrated platform supporting and managing increased decentralization of generation and digitalization of grid and customers in support of NYS energy policy goals: Test and prove value of foundational platform technologies Develop new capabilities and processes that support the evolution of utility functionality Create and test new rate designs that support system efficiency Identify new methods for creating value for customers Identify new methods for engaging with the market Create an environment of collaboration Support and inform clean energy policy Phase 1 Pre Planning Regulatory Approval Document project objectives & milestones Budget, resource planning Phase 2 Implementation Plan Development Implementation Plan developed and filed RFPs issued and awarded Baseline data and market research completed PMO and Governance established Stakeholder Engagement and Customer Outreach starts Phase 3 Foundational Infrastructure AMI network completed and functional automation work completed Phase 4 Enabling Technology Innovative rates filed and approved Billing functionality completed Marketplace and customer portal completed Phase 5 Future Opportunities Pipeline development and processes Additions to customer portal, marketplace etc

Glutathiones half-life in plasma is approximately 90120 minutes regardless of injection route the peptide degrades via gamma-glutamyl transpeptidase at a consistent rate once in circulation

however, serum ALT level in aged mice was not differ from young mice