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Despite notable advances in treatment strategies, optimizing healing outcomes, particularly in chronic wounds, remains a major challenge

Piga R, Naito Y, Kokura S, Handa O, Yoshikawa T

A phenomenon known as ROS-induced ROS release (RIRR) can occur when the ROS generated stimulate the formation of new ROS via the opening of the mitochondrial permeability transition pore, thereby amplifying intracellular oxidative stress

How to combine and optimize the different available measures, including chemotherapy, behavioral change, and environmental control, will determine the cost and effectiveness and help to identify the ideal measures for short-term morbidity control, long-term transmission control, and even interruption