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The presence of activated myelin-reactive T cells and their receptors, plasma cells and macrophages, the pathologic features of the lesions and the frequent presence of excessively higher immunoglobulin levels in the CSF have all been used to corroborate the theory that MS is an immune-mediated disorder [32]

The researchers described these effects as "relatively mild, predictable, and reversible renal injury and altered tubular function." That description is accurate but perhaps understates the significance of what they observed