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Furthermore, CatG participates in complex inflammatory response regulation processes, including cytokine, chemokine, and growth factor processing and activation, as well as apoptosis induction through protease three pathways ( In pathological states such as bronchiectasis and COPD, NSP activity in sputum and bronchoalveolar lavage fluid increases markedly, with activity levels correlating positively with disease severity, acute exacerbation risk, and lung function decline rates ( 2.3 Role of DPP1 in NSP activation DPP1 plays an essential role in activating NSP precursor proteins during neutrophil maturation

Animal studies indicate dose-dependent effects, with toxic doses possibly affecting copper metabolism or interacting with embryonic development in hypersensitive models, warranting caution during pregnancy

Human clinical trials for MOTS-c are underway but not yet published in their final forms

Autonomic nerve dysfunction in COPD as assessed by the acetylcholine sweat-spot test