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The share approached 15% by week 88 in the longest trial, while clinical underweight remained below 0.5%. The signal clustered in lower-baseline deep responders

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Native IGF-1 has a frustrating pharmacokinetic limitation: it binds tightly to a family of IGF binding proteins (IGFBPs, particularly IGFBP-3) that sequester it in circulation and keep its free half-life to roughly 15-20 minutes