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This gradient mechanismranging from low-concentration signaling blockade to high-concentration multi-pathway synergyexhibits concentration-dependent anti-inflammatory activity in LPS-stimulated HaCaT keratinocytes (1.520 M), with no cytotoxicity observed below 6 M (Nguyen et al., 2022)

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This finding is consistent with other reports that these genes expression typically peaks during early progenitor stage and decreases towards the final hepatocyte-like cells stage 24,25,26

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