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2 Materials and methods 2.1 Search strategy A systematic literature search was performed using the PubMed, Web of Science, Embase, and Cochrane databases, as well as the China National Knowledge Infrastructure (CNKI) in December 2023 using the following search terms: (Hashimoto Disease[MeSH Terms]) OR (Disease, Hashimoto[Other Term]) OR (Chronic Lymphocytic Thyroiditis[Other Term]) OR (Chronic Lymphocytic Thyroiditides[Other Term]) OR (Lymphocytic Thyroiditides, Chronic[Other Term]) OR (Lymphocytic Thyroiditis, Chronic[Other Term]) OR (Thyroiditides, Chronic Lymphocytic[Other Term]) OR (Thyroiditis, Chronic Lymphocytic[Other Term]) OR (Hashimoto Struma[Other Term]) OR (Hashimotos Struma[Other Term]) OR (Hashimotos Syndrome[Other Term]) OR (Hashimoto Syndrome[Other Term]) OR (Hashimotos Syndromes[Other Term]) OR (Hashimotos Syndrome[Other Term]) OR (Syndrome, Hashimotos[Other Term]) OR (Syndromes, Hashimotos[Other Term]) OR (Hashimotos Disease[Other Term]) OR (Disease, Hashimotos[Other Term]) OR (Hashimotos Disease[Other Term]) OR (Hashimoto Thyroiditis[Other Term]) OR (Hashimoto Thyroiditides[Other Term]) OR (Thyroiditides, Hashimoto[Other Term]) OR (Thyroiditis, Hashimoto[Other Term]) AND (selenium[MeSH Terms]) OR (Vitamin d[MeSH Terms]) OR (Myo-inositol[MeSH Terms])

The phenomena of downregulation of LH-RH receptors by LH-RH agonists have important critical applications 3

Ruffin et al., 2020) making this transporter a druggable target (Karunakaran et al., 2011)

Mucosal Versus Submucosal Lymphovascular Invasion in Early Esophageal Cancer