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Therefore, to investigate the mechanisms underlying demyelination and remyelination, we established an alternative CPZ mouse model and detected the metrics of this model at a series of dynamic time points by ultrahigh-field multiparameter MRI

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Notably, avidin-conjugated dexamethasone demonstrated superior efficacy in inhibiting IL-1-driven aggrecan breakdown in cartilage explant cultures compared with soluble dexamethasone, 63 underscoring the potential of this approach

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