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In general, the harmful effects of excess ROS on the cell most often include damage of DNA, oxidation of polyunsaturated fatty acids (PUFA) in lipids (lipid peroxidation), oxidation of amino acids in proteins and oxidatively inactivate specific enzymes by oxidation of co-factors (Brenneisen et al., 2005

J., Keever A., Liljenberg C., Kirby T., Magori K., et al

doi: 10.1111/1462-2920.13589 58 LiuYLiuGFangJ

Thromb Haemost 113:494504 Papp LV, Lu J, Holmgren A, Khanna KK (2007) From selenium to selenoproteins: synthesis, identity, and their role in human health