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Experimental supplementation studies in women with PCOS reveal that nocturnal melatonin (25 mg) improves fasting glucose, HOMA-IR, and adiponectin levels while reducing androgen concentrations and oxidative biomarkers (199)

TABLE 15.5 Lipid Cut Points (mg/dL) Values represent approximately the *75th and **95th percentiles and approximately the ***10th percentile for low HDL-C

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Published protocols also note pregnancy, known hypersensitivity to IGF-1 analogs, and pre-existing insulin resistance or diabetes as conditions requiring exclusion or enhanced monitoring in study design