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Sikiric and colleagues have proposed nitric oxide system involvement, while other groups have documented effects on VEGF receptor 2 expression, growth-hormone receptor upregulation, and dopamine pathway modulation

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The anti-aging skin claims are supported by in vitro, animal, and observational human data, which is consistent with what providers and patients report clinically

Dig Dis Sci 1997 (in press) Sikiric P, Mikus D, Seiwerth S, Grabarevic Z, Rucman R, Petek M, Jagic V, Turkovic B, Rotkvic I, Mise S, Zoricic I, Konjevoda P, Perovic D, Simicevic V, Separovic J, Hanzevacki M, Ljubanovic D, Artukovic B, Bratulic M, Tisljar M, Rekic B, Gurasin M, Miklic P, Buljat G: Pentadecapeptide BPC 157 positively affects both non-steroidal anti-inflammatory agents-induced gastrointestinal lesions and adjuvant arthritis in rats