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While detailed human studies are limited, MS involves gut dysbiosis that influences immune regulation, with preclinical data suggesting certain bacterial taxa may modulate neuroinflammatory responses

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However, when the three markers were combined for disease prediction, the integration of SII, NLR, and maximum appendiceal diameter demonstrated a significant linear relationship and enhanced diagnostic performance.To compare with classical clinical scoring systems, we performed ROC analysis of the Alvarado score in all 207 patients (Figure 5)

Therefore, we propose two translational perspectives