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10.1016/S0896-6273(01)00264-1 Neuron 148 PratM.CrepaldiT.PennacchiettiS.BussolinoF.ComoglioP

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Metabolic modulators such as Ninerafaxstat, a 3-ketoacyl-CoA thiolase (3-KAT) inhibitor, are in phase IIb trials for symptomatic nonobstructive hypertrophic cardiomyopathy, which has demonstrated improved cardiac energy metabolism and functional capacity in patients (ClinicalTrials.gov ID [NCT07023614])