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doi: 10.1016/j.neuro.2010.05.008 20 BenkiraneA.WarlopT.IvanoiuA.BaretP.WiameE.HaufroidV.et al

Do not double the dose to make up for the missed one.

Hence, the presence of a site displaying spatial characteristics that differ from those of typical drug-like molecules could have had a detrimental effect on the druggability score