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For instance, induction of iNOS in microglia leads to a decrease in cellular GSH level, whereas, under comparable conditions, the GSH status of astrocytes remains largely unaffected ( - exposure ( The role of GSH as NO scavenger is also highlighted by To investigate the importance of correct GSH homeostasis for the neurotrophic capacity of NO, 2 -Tyr) protein accumulation ( Figure 1 )

Notably, individuals at the extremes of age, both infants and the elderly, as well as those with pre-existing comorbidities, particularly cardiopulmonary disorders, are at markedly increased risk (490)

doi: 10.1016/S0014-5793(03)00277-1 186 SeidlS

Glutathione peroxidase (GPX) role in oxidative stress and its interaction with superoxide dismutase (SOD) The SOD gene locus resides on chromosome 21 and as a consequence of gene dosage excess, SOD activity has been shown to be increased by about 50% in all tissues of patients with Down syndrome (Brooksbank & Balzas, 1983