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These impairments were reversed with adequate copper consumption (Elsherif et al., 2003

Ellis JA, Ponsonby AL, Pezic A, Williamson E, Cochrane JA, Dickinson JL, et al

Studies have found that there are several ways to ultimately attenuate renal IRI by inhibiting the activation of the NLRP3 inflammasome, such as using hydrogen sulfide (H2S) [49], -hydroxybutyrate (-OHB) treatment [50], inhibiting mTORC1 with activated protein C (aPC) [51], and promoting zinc ion influx in renal TECs with transient receptor potential-6 (TRPC6) [52]