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Description

10.1016/j.sjopt.2018.05.002 236

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The above experiments in vivo and in vitro have confirmed that TMAO can cause inflammation of endothelial cells, and similar results can be observed in humans

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J Biol Chem 254(4):12051210 Griffith OW, Meister A (1979) Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine)

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While the exact mechanism behind this phenomenon remains inadequately understood and needs to be fully elucidated, several factors have emerged as potential contributors, including the role of VEGF, the involvement of angiopoietin-2, adiponectin deficiency, along hypoxic conditions

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