Although ferroptosis was initially identified in studies that were associated with cancer, it has been demonstrated to fulfill a crucial role in the progression and toxicity of numerous neurological diseases, including stroke (198), Parkinson's disease (199) and Alzheimer's disease (32)
And so maybe she wouldnt have done mitochondrial testing with me until months after that, but it wouldnt have been a big deal because she had this real-time indicator of mitochondrial dysfunction that she tested herself at home that showed her, oh, Im trying this out of left field thing
Disrupting MYSM1 (Myb like, SWIRM and MPN domains 1), a histone deubiquitinase, can compromise human HSC function, mimicking the bone marrow failure seen in patients, by triggering lipid peroxidation and ferroptosis [203]
How the HPA axis and oxidative stress pathways activated by heat stress precisely regulate the transcriptional expression of immune molecules (e.g., antimicrobial peptides, cytokines), as well as key regulatory molecules (e.g., interactions between transcription factor NF-B and stress signals), remain unclear
