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It has been demonstrated that, together with the regulation of CPT1 by malonyl-CoA, acetylation of CACT plays a crucial role in the control of the influx of fatty acyl units into mitochondria 57

People who are pregnant or breastfeeding, those with kidney disease, seizure disorders, or thyroid conditions, and anyone on medications that could interact should avoid it unless a physician specifically approves it

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Four -ketoacid dehydrogenase complexes ( Figure 4 ), including: (i) the pyruvate dehydrogenase complex that catalyzes the conversion of pyruvate to acetyl-coenzyme A (CoA), an important substrate for energy production via the citric acid cycle