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Naturally released by the human gut and vital in appetite regulation and weight management, research has revealed that supplementation in obese patients can help reduce the latter's BW by 20% or more

Six controlled trials in approximately 900 participants are summarized in Stier et al

This mechanism is especially relevant in neurons, where curcumin selectively targets pathologically altered or dysfunctional cells for apoptosis while exerting minimal cytotoxicity on healthy neuronal populations

Nunes-Souza V, Csar-Gomes CJ, Da Fonseca LJ, Guedes Gda S, Smaniotto S, Rabelo LA (2016) Aging increases susceptibility to high fat diet-induced metabolic syndrome in C57BL/6 mice: improvement in glycemic and lipid profile after antioxidant therapy