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Description

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Increased pain sensitivity is another prominent feature in comorbid patients, with visceral hypersensitivity being key in this process, as central and peripheral sensitization together lead to pain symptom amplification (Whitehead et al., 2002)

CONCEAConselho Nacional de Controle de Experimentao Animal (2013) Diretrizes da Prtica de Eutansia do CONCEA

Close cooperation among material scientists, pharmacologists, immunologists, and clinicians is needed-not only to assess therapeutic efficacy but also to design rational preclinical and clinical studies grounded in real clinical needs