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the prefrontal cortex, involved in attention and cognitive control, becomes dysregulated, preventing patients from ignoring the tinnitus (De Ridder et al., 2014

Kolkhof P, Brfacker L

doi: 10.1016/j.biopsych.2015.04.005, 30 MikkelsenM.TapperS.NearJ.MostofskyS

In animals exposed to intense noise, MAPK phosphorylation in the cochlea is altered, ERK1/2 in the sensory and support cells of the cochlear sensory epithelium are activated by phosphorylation