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Pro tip: Oversizing a system can be just as problematic as undersizing, especially if your well pump cant provide the proper flow for backwashing

Periodontitis is another highly prevalent chronic inflammatory disease, initiated by bacterial biofilms that lead to the progressive destruction of tooth-supporting tissues [6]

The main outcome variable to be monitored in both treatment arms is the normalisation of the serum vitamin B12 concentration at weeks 8, 26 and 52